Abstract
Electric-field-induced cell membrane permeabilization (electroporation) is used in a wide range of applications, from cancer therapy to food processing. The mechanisms underlying this phenomenon are, however, poorly understood. Electroporation is generally thought to involve the formation of transient pores, and perhaps other conductive structures, in the cell membrane. This enables the transport of normally impermeant material across the membrane and disrupts the intracellular:extracellular ion concentration gradients (Na+, K+, Cl-) maintained by intact cells.
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