Time Encoding in olfactory fear conditioning in rats.

Abstract

Event Abstract Back to Event Time Encoding in olfactory fear conditioning in rats. Kiseko Shionoya1*, Chloe Hegoburu1, Samuel Garcia1, Marc Thevenet1, Belkacem Messaoudi1 and Anne-Marie Mouly1 1 CNRS UMR 5020, Neurosciences Sensorielles, Comportement & Cognition, France Timing and time perception are crucial to survival and goal reaching in humans and other animals and interval timing also guides fundamental animal behaviours. In fear conditioning paradigm an initially neutral stimulus (the conditioned stimulus) predicts the arrival of an aversive unconditioned stimulus (generally a mild foot-shock) at a fixed time interval. After a few trials, re-exposure to the conditioned stimulus alone elicits fear responses such as freezing. Accumulating experimental evidence has made it clear that in associative learning temporal relations between events are encoded. However very few studies have specifically addressed the question of the long-term memory of time and its underlying neural network in fear conditioning. In a recent study we used high temporal resolution microdialysis for studying amino acids changes in amygdala and olfactory cortex during odor fear acquisition session. We observed an early response in the amygdala during the first odor-shock trial while in the olfactory cortex changes were detected after each trial, and were also observed after the end of the pairings, at the predicted time of occurrence of an anticipated trial, suggesting an involvement of the cortex in encoding the intertrial interval duration. In the present study we developed the monitoring of two physiological parameters involved in fear response: respiration and ultrasonic vocalizations. These parameters added to freezing response greatly improve the sensitivity of the behavioral assessment of fear response, thus increasing the probability of detecting anticipatory fear responses suggestive of time encoding in odor fear conditioning. Current experiments are carried out to identify some of the key structures involved in this time encoding. We are mainly focusing on the amygdale, striatum, and prefrontal cortex because these structures are involved in time encoding in the seconds-minutes range and are also known to send projections to the olfactory cortex. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Shionoya K, Hegoburu C, Garcia S, Thevenet M, Messaoudi B and Mouly A (2009). Time Encoding in olfactory fear conditioning in rats.. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.299 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Jun 2009; Published Online: 15 Jun 2009. * Correspondence: Kiseko Shionoya, CNRS UMR 5020, Neurosciences Sensorielles, Comportement & Cognition, Lyon, France, kshiono@olfac.univ-lyon1.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kiseko Shionoya Chloe Hegoburu Samuel Garcia Marc Thevenet Belkacem Messaoudi Anne-Marie Mouly Google Kiseko Shionoya Chloe Hegoburu Samuel Garcia Marc Thevenet Belkacem Messaoudi Anne-Marie Mouly Google Scholar Kiseko Shionoya Chloe Hegoburu Samuel Garcia Marc Thevenet Belkacem Messaoudi Anne-Marie Mouly PubMed Kiseko Shionoya Chloe Hegoburu Samuel Garcia Marc Thevenet Belkacem Messaoudi Anne-Marie Mouly Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.