Abstract
Patients with psoriatic arthritis (PsA) have a higher risk of cardiovascular disease (CVD) compared with the general population. Inflammation and traditional CVD risk factors (RFs), including dyslipidemia, make a significant contribution to the development of CVD and their complications in patients with PsA. Objective: to assess the time course of changes in lipid profile measures in patients with early PsA (ePsA) during adalimumab (ADA) treatment for 3-months. Subjects and methods. The investigation enrolled 16 patients (11 women, 5 men; median (Me) age, 45.5 years) with early PsA (ePsA) (disease duration, 7.7 months). ADA was administered subcutaneously at doses of 40 mg once every 2 weeks for 3 months. Before and 3 months after the start of ADA therapy, DAS, C-reactive protein levels, and traditional CVD RFs, including lipid profile measures (total cholesterol, TC, low-density lipoprotein cholesterol, LDL-C, triglycerides, TG, high-density lipoprotein cholesterol, HDL-C, and atherogenic coefficient, AC) were estimated. Ten-year risk for fatal CVD was assessed using the SCORE scale. Results and discussion. Lipid profile disorders mainly associated with elevated LDL-C levels were revealed in 11 (69%) patients; according to the SCORE scale, the total 10-year risk for fatal CVD was low and moderate in 10 (62.5%) and 6 (37.5%) patients, respectively. A correlation was found between the baseline DAS and TG (r=0.53; p 0.05). Conclusion. Lipid profile changes were found in 69% of patients with ePSA and correlated with disease activity. The lower inflammatory activity during ADA therapy was accompanied by elevated TC and TG levels.
Highlights
TIME COURSE OF CHANGES IN LIPID PROFILE MEASURES IN PATIENTS WITH EARLY PSORIATIC ARTHRITIS DURING ADALIMUMAB THERAPY Markelova E.I., Novikova D.S., Korotaeva T.V., Loginova E.Yu
Lipid profile disorders mainly associated with elevated LDL-C levels were revealed in 11 (69%) patients; according to the SCORE scale, the total 10-year risk for fatal cardiovascular disease (CVD) was low and moderate in 10 (62.5%) and 6 (37.5%) patients, respectively
There were no significant changes in the level of LDL-C and HDL-C, and CA, their medians at the beginning and end of therapy were 3.3 [2.8; 4.1] and 3.6 [3.3; 4.1]; 3.0 [1.2; 1.5] and 1.3 [1.2; 1.6]; 2.6 [2.3; 3.6] and 3.2 [2.4; 3.6] mmol/L, respectively
Summary
Маркелова Е.И., Новикова Д.С., Коротаева Т.В., Логинова Е.Ю. Пациенты с псориатическим артритом (ПсА) имеют более высокий риск развития сердечно-сосудистых заболеваний (ССЗ) по сравнению с общей популяцией. Цель – оценить динамику показателей липидного профиля у больных ранним ПсА (рПсА) на фоне терапии адалимумабом (АДА) в течение 3 мес наблюдения. До и через 3 мес после начала терапии АДА у всех пациентов определяли индекс DAS, уровень С-реактивного белка (СРБ), традиционные ФР ССЗ, в том числе показатели липидного профиля: уровень общего холестерина (ОХС), холестерина липопротеидов низкой плотности (ХС ЛПНП), триглицеридов (ТГ), холестерина липопротеидов высокой плотности (ХС ЛПВП) и коэффициент атерогенности (КА). Before and 3 months after the start of ADA therapy, DAS, C-reactive protein levels, and traditional CVD RFs, including lipid profile measures (total cholesterol, TC, low-density lipoprotein cholesterol, LDL-C, triglycerides, TG, high-density lipoprotein cholesterol, HDL-C, and atherogenic coefficient, AC) were estimated. Lipid profile disorders mainly associated with elevated LDL-C levels were revealed in 11 (69%) patients; according to the SCORE scale, the total 10-year risk for fatal CVD was low and moderate in 10 (62.5%) and 6 (37.5%) patients, respectively. There was a tendency to increase the frequency of non-target TC values from 44 to 75%, LDL-C from 69 to 81%, TG from 12.5 to 19%, and AC from 37.5 to 62.5% (p>0.05)
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