Abstract
TIMAP is enriched in the endothelium and highly expressed in macrophages. TIMAP is suppressed by TGFβ via HDAC3-associated Smad signaling. TIMAP inhibits TGFβ signaling and TGFβ-associated macrophage M2 polarization. TIMAP dephosphorylation of MLC counteracts TGFβ-induced macrophage phagocytosis.
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