Abstract
Tim-4 is a member of the T-cell immunoglobulin mucin (Tim) family of proteins that has been implicated in thecontrol of T cell-mediated immune responses. Tim-4 that is expressed on various macrophages subsets has beenrecognized as a phosphatidylserine receptor mediating phagocytosis of apoptic cells by peritoneal macrophages.The functions of Tim-4 in immune responses, however, are still unclear. In this study, results showed that blockingof Tim-4 that is preferentially expressed on F4/80+ peritoneal macrophages results in increased C04+ T cellsproliferation. Additionally the administration of anti-Tim4 monoclonal antibody decreased the percentage ofFoxp3+CD4+CD25+ T-regulatory cells in lymph nodes of immunized mice suggesting an emerging role of Tim-4molecule in immune regulation as a promising target for treatment and prevention of autoimmune diseases.
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