Abstract
The TIM (T cell immunoglobulin mucin) proteins are emerging as critical regulators of T helper (Th) cell responses and as potential susceptibility factors for the development of allergic and autoimmune diseases. On page 437, Chakravarti and colleagues add to the developing TIM story by showing that TIM-2 is preferentially expressed on differentiated Th2 cells and inhibits their expansion and function. These molecules, according to senior author Vijay Kuchroo, are not only critical modulators of the CD4+ Th cell response, but are the first reliable markers of differentiated Th cell subsets.
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