Abstract
Sulfur-containing amino acids, including cysteine (Cys) and homocysteine (Hcy), as well as aldehydes such as formaldehyde (FA), acetaldehyde (AA), pyridoxal 5`-phosphate (PLP), acrolein (ACR), malondialdehyde (MDA), croton aldehyde (CA) and 4-hydoxynonenal (4-HNE) widely occur in the human body. As indicated in the literature, abnormal (elevated) concentrations of these compounds in humans may result in or even be the cause of the occurrence/development of some civilization diseases. At the same time, the literature provides the evidence that Cys and Hcy are a highly reactive towards aldehydes resulting in formation of substituted thiazolidine and thiazine carboxylic acids, respectively. Importantly, it has been shown that these adducts are formed in vitro and in vivo, while chromatographic techniques are suitable for their monitoring in biological samples. In this work, the above-mentioned issues are discussed. In particular, Cys and Hcy as well as selected endogenous aldehydes are characterized, and their role in human body in health and disease is discussed. Moreover, chromatographic methods enabling determination of selected adducts of Cys and Hcy with the above-mentioned aldehydes in biological samples are described.
Published Version
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