Abstract
Thyrotropin releasing hormone (TRH) is known to stimulate prolactin secretion but it is not known whether TRH is the physiological prolactin releasing factor (PRF) or whether the TRH effect on prolactin secretion is a pharmacological action. Normal male rats were implanted with permanent right atrial cannulae and sequential blood samples were taken every min through the cannula. Ether stress elevated plasma prolactin to more than 3 times the normal concentration, while plasma TSH was not changed. However, TRH raised plasma TSH to more than 5 times the normal concentration, while the elevation of plasma prolactin concentration was marginal. The dissociation between the elevation of plasma TSH and prolactin concentrations with ether stress and TRH injection indicates that TRH is not the physiological PRF.
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