Abstract
IT IS well established that the thyroid possesses a mechanism whereby it concentrates (“traps”) inorganic iodide (VanderLaan and VanderLaan, 1947; Taurog et al., 1947). Studies using tracer doses of radioactive iodine have disclosed the thyroid: serum iodide gradient to be profoundly influenced by thyrotrophin (TSH) (VanderLaan and VanderLaan, 1947; Vander- Laan and Greer, 1950; Ingbar and Roberts, 1952; Halmi et al., 1953). Up to 100 jug of stable iodide carrier added to the tracer had no appreciable effect on the thyroid: serum radioiodide concentration ratio (T/S) of normal (VanderLaan and VanderLaan, 1947) or of goitrous rats (Vander- Laan and VanderLaan, 1947; Taurog xyiet al., 1947). However, further increase of the dose of stable iodide caused the T/S of propylthiouracil (PTU)-treated rats to drop (VanderLaan and VanderLaan, 1947; Wyngaarden et al., 1953). This suggested to Raben and Astwood (1949) that the capacity of the thyroid for iodide is limited, and indeed
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