Abstract
Background. Conventional management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery while adjunctive treatment includes beta-blockers, corticosteroids, inorganic iodide and iopanoic acid. Very rarely, patients may be resistant to these modalities and require additional management. Case Presentation. A 50-year-old lady presented with weight loss and palpitations diagnosed as atrial fibrillation. Her past history was significant for right thyroid lobectomy for thyrotoxicosis. Thyroid functions tests at this presentation showed free T4 of 6.63 ng/dl (normal range: 0.93–1.7) and TSH of <0.005 μIU/mL (normal range: 0.4–4.0). She was given aspirin, propranolol, heparin and carbimazole; however free T4 failed to normalize. Switching to propylthiouracil (PTU) did not prove successful. She was then given high doses of prednisolone (1 mg/kg/day) and lithium (400 mg twice daily) which prepared the patient for radioactive iodine treatment by reducing free T4 levels (2.82 ng/dl). Two doses of radioactive iodine were then administered 6 months apart. Subsequently she became hypothyroid and was started on thyroid replacement therapy. Conclusion. This case highlights management options in patients with resistant thyrotoxicosis. Radioactive iodine and surgery are definitive modes of treatment in such complex cases while steroids and lithium play an important role in preparing patients for more definitive treatment.
Highlights
Conventional management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery while adjunctive treatment includes beta-blockers, corticosteroids, inorganic iodide and iopanoic acid
Adjunctive treatment in the form of beta-blockers, corticosteroids, inorganic iodide, and iopanoic acid may be used for more prompt control of symptoms [3,4,5,6]
We have described a case of thyrotoxicosis in a patient with Graves disease that was resistant to antithyroid drugs
Summary
Thyrotoxicosis affects approximately 2% of women and 0.2% of men [1]. Graves disease is the most common cause of thyrotoxicosis. It is an autoimmune disorder characterized by a constellation of clinical features including hyperthyroidism, diffuse goitre, ophthalmopathy, and dermopathy [2]. Conventional principal management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery. A few cases may require additional treatment despite these conventional modalities to achieve euthyroid state. We have described a case of thyrotoxicosis in a patient with Graves disease that was resistant to antithyroid drugs. High-dose steroids and lithium were administered to improve her thyrotoxicosis so that radioactive iodine could be administered later
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