Abstract
Background : Thyroid volume correlates positively with body mass index (BMI). This correlation holds true for both iodine-sufficient and mild/moderate iodine-deficient areas. We examined the association between thyroid volume and BMI and change in BMI over 4 years in middle-age adults recruited from the general population. Methods : A total of 2,495 subjects, for whom thyroid volume, FT4 and TSH were available (women aged 35 - 60 years and men aged 45 - 60 years), were derived from the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI. MAX) cohort study conducted in France since baseline (1994). Weight and height were measured 2 and 6 years after inclusion. Linear univariate and multiple regression analyses were performed to evaluate correlations between thyroid volume and BMI at 2 and 6 years and BMI change from year 2 to 6. Results : Baseline thyroid volume was positively correlated with BMI at 2 years (men: beta = 0.09, P Conclusion : In French adults, thyroid volume predicted BMI at 2 and 6 years. Further studies are needed to explore the association between thyroid volume and BMI. doi:10.4021/jem99w
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