PD39-10 CHANGES IN BODY MASS INDEX AND METABOLIC SYNDROME ARE ASSOCIATED WITH PROSTATE GROWTH RATE OVER A 5 YEAR PERIOD

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You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History1 Apr 2015PD39-10 CHANGES IN BODY MASS INDEX AND METABOLIC SYNDROME ARE ASSOCIATED WITH PROSTATE GROWTH RATE OVER A 5 YEAR PERIOD Yoon Soo Kyung, Dalsan You, In Gab Jeong, Taekmin Kwon, Chunwoo Lee, Seungbong Han, Hong-Kyu Kim, Choung-Soo Kim, Myungchan Park, Chanwoo Lee, and Sangjun Yoo Yoon Soo KyungYoon Soo Kyung More articles by this author , Dalsan YouDalsan You More articles by this author , In Gab JeongIn Gab Jeong More articles by this author , Taekmin KwonTaekmin Kwon More articles by this author , Chunwoo LeeChunwoo Lee More articles by this author , Seungbong HanSeungbong Han More articles by this author , Hong-Kyu KimHong-Kyu Kim More articles by this author , Choung-Soo KimChoung-Soo Kim More articles by this author , Myungchan ParkMyungchan Park More articles by this author , Chanwoo LeeChanwoo Lee More articles by this author , and Sangjun YooSangjun Yoo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2405AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent studies indicate that BPH and prostatic enlargement are linked with modifiable factors, including obesity and metabolic syndrome (MetS). However, the association between the changes in these factors over time in the general population is unclear. Therefore, too evaluate the relationship between changes in body mass index (BMI), waist circumflex (WC), MetS and prostate growth over 5 years in an adult population. METHODS Data were collected from 1,108 population-based men age ≥ 40 years without a history of prostate cancer who underwent at least three general health screenings with a duration about 5 years between 2006 and 2013. Percent change in prostate volume (PV) was assessed 5 years following baseline measurements. Rates of prostate growth, body weight, and WC change over 5 years were calculated using the following formula: [(5 years after PV - base PV) / base PV] x 100. Association between prostate growth and changes in BMI, WC, and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses. RESULTS Mean PVs were 21.3 ± 6.6 cc (baseline) and 28.21 ± 9.7 cc (5-year follow up). The mean BMI and waist circumference (WC) were 24.89 ± 2.59 kg/m2 and 86.79 ± 6.9 cm (baseline) and 24.68 ± 2.65 kg/m2 and 87.86 ± 7.4 cm (5-year follow up). After univariate linear regression, initial PSA, initial PV, initial BMI, changes in weight, BMI and WC were correlated with prostate growth. By multivariate linear regression analysis, changes in weight, BMI and WC were significantly associated with prostate growth (p = < 0.01, < 0.01 and 0.03, respectively) after adjusting for age, initial PV, and initial BMI. (Table) Prostate growth and changes in BMI were correlated in the obese group [initial BMI ≥ 25 kg/m2; 0.926 (0.376 to 1.475), p = < 0.01] but not in the non-obese group [initial BMI < 25 kg/m2; 0.455 (-0.050 to 0. 960), p = 0.12]. Patients who developed MetS exhibited greater prostate growth than those who did not [6.795 (1.589 to 12.001), p = 0.01]. CONCLUSIONS Changes in weight, BMI, and MetS status affect prostate growth over a 5-year period. Obese men show a particularly strong correlation between changes in BMI and prostate growth. Therefore, weight loss and controll MetS would improve prostate growth rate. Table. Factors associated with prostate growth rate according to linear regression analysis Univariate ∗Multivariate Coefficient estimate 95% CI p Coefficient estimate 95% CI p Change in weight % 0.597 0.220-0.974 <0.01 0.662 0.287-1.036 <0.01 Change in BMI % 0.525 0.153-0.897 <0.01 0.623 0.253-0.993 <0.01 Change in WC % 0.368 0.014-0.722 0.04 0.381 0.032-0.730 0.03 PSA 3.059 1.247-4.870 <0.01 3.954 0.647-7.260 0.02 BMI 0.669 0.027-1.310 0.04 1.119 0.117-2.120 0.03 Age -0.106 -0.342-0.130 0.38 0.029 -0.215-0.275 0.81 Base prostate volume -0.386 -0.638−-0.134 <0.01 -0.595 -1.001−-0.189 <0.01 ∗ Adjustment age, PSA, BMI, base prostate volume. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e833-e834 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yoon Soo Kyung More articles by this author Dalsan You More articles by this author In Gab Jeong More articles by this author Taekmin Kwon More articles by this author Chunwoo Lee More articles by this author Seungbong Han More articles by this author Hong-Kyu Kim More articles by this author Choung-Soo Kim More articles by this author Myungchan Park More articles by this author Chanwoo Lee More articles by this author Sangjun Yoo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...