Abstract
Background: Chronic kidney disease (CKD) is defined as abnormalities in kidney structure or functionpresent for > 3 months and have other health implications. Thyroid hormones are important for electrolytehomeostasis and also for the growth and development of the kidney. Study shows that hypothyroidism iscommonly seen in later stages of CKD. This study was conducted to investigate thyroid hormone profile andits correlation with creatinine in CKD patients.Materials and Methods: The present case control study was conducted at Dhiraj General Hospital, Piparia,Vadodara, Gujarat, India in which 100 subjects were enrolled, out of which 50 were cases of CKD patientsand 50 were controls. The age group for the study was 18 to 70 years. Blood samples were drawn to measureblood urea, serum creatinine, thyroid profile. Interpretation of data was done using Medcalc software.Conclusion: Serum TSH levels were high in cases compared to controls but results were not significant.Significant negative correlation was found between free thyroid hormones and serum creatinine. Correlationof creatinine with T3, T4 and TSH were not significant. Subclinical hypothyroidism is found in our populationwith undialyzed CKD. More studies involving large population size are required to ascertain these findings.
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