Association of Serum Creatinine with Thyroid Hormone Profile in Chronic Kidney Disease Patients

Abstract

This study was conducted to investigate thyroid hormone profile and its correlation with creatinine in CKD patients. Anomalies in kidney structure or function that have been present for more than three months are referred to as chronic kidney disease (CKD) and have negative effects on health. The growth and development of the kidney as well as the maintenance of electrolyte homeostasis depend on thyroid hormones. The kidney controls thyroid hormone metabolism, degradation, and excretion; renal dysfunction affects thyroid hormone synthesis, distribution, and excretion. In the later stages of CKD, hypothyroidism is frequently observed, according to a study. . The present case control study was conducted at Dhiraj General Hospital, Piparia, Vadodara, Gujarat, India in which 100 subjects were enrolled, out of which 50 were cases of CKD patients and 50 were controls. The age group for the study was 18 to 70 years. Blood samples were drawn to measure blood urea, serum creatinine, thyroid profile. Interpretation of data was done using Medcalc software. Data were collected by personal interview, with every individual. Performa was available for the filling of biodata like age and gender, clinical examination findings and investigations. The mean level of T3 was 0.87±0.52 in cases and 1.74±1.97 in controls, difference between them was statistically significant. The mean level of T4 was 5.09±1.19 in cases and 6.11±1.28 in controls, difference between them was statistically not significant. Serum TSH levels were higher in cases than in controls, but the differences were not statistically significant. Free thyroid hormones and serum creatinine were found to have a strong negative correlation. Correlation of creatinine with T3, T4 and TSH were not significant. Subclinical hypothyroidism is found in undialyzed CKD patients. More studies involving large population size are required to ascertain these findings. In order to stop further cardiovascular complications, it's critical to screen CKD patients for thyroid gland dysfunction because hypothyroidism can lead to cardiovascular complications in CKD patients.