Abstract

Thyroid hormone(TH) is an important hormone for maintaining normal metabolism,thyroid hormone receptor (TR) and its isoforms distribute in different tissues with different effects.TR β acts mainly in liver and participates in lipid metabolism.TH is closely associated with hyperlipemia,obesity,insulin resistance and nonalcoholic fatty liver disease (NAFLD).TRα antagonist,TRβ agonist and TH analogue show therapeutic effects of NAFLD. Key words: Thyroid hormone; Thyroid hormone receptor; Nonalcoholic fatty liver disease; Obesity

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