Changes of thyroid hormone levels in patients with non-alcoholic liver disease and its significance

Abstract

Objective To investigate the changes of thyroid hormone levels in patients with non-alcoholic liver disease and its significance. Methods Fifty patients with non-alcoholic liver disease treated in Puning People’s Hospital from January 2018 to December 2018 were randomly selected, including 18 cases of non-alcoholic steatohepatitis and 32 cases of non-alcoholic fatty liver, 18 cases of mild fatty liver, 17 cases of moderate fatty liver, 15 cases of severe fatty liver. Another 50 healthy persons who underwent physical examination during the same period were selected. All subjects underwent radioimmunoassay to detect related serum indicators, for example total triiodothyronine (TT3). And their correlations were analyzed. Results The levels of TT3 in non-alcoholic steatohepatitis, non-alcoholic simple fatty liver disease patients, and healthy people were (0.96±0.17) ng/ml, (1.04±0.15) ng/ml, and (1.28±0.23) ng/ml, respectively. There were statistically significant differences in TT3 levels among them (P<0.05). The levels of TT3 in patients with moderate fatty liver, severe fatty liver were (0.98±0.16) ng / ml, (0.88±0.23) ng/ml lower than the (1.28±0.23)ng/ml in healthy people (P<0.05). TT3 levels in patients with non-alcoholic fatty liver were negatively correlated with levels of hyaluronic acid (HA) and amino terminal peptides of type Ⅲ procollagen, and TT3 levels in patients with non-alcoholic steatohepatitis were negatively correlated with HA, laminin, and type IV collagen. Conclusions The level of TT3 in patient with non-alcoholic liver disease is decreased, and it is correlated with the degree of liver fibrosis. And it can be used to evaluate the disease condition, which is beneficial to the clinical diagnosis and treatment of non-alcoholic liver disease. Key words: Thyroid hormone; Triiodothyronine; Non-alcoholic liver disease