Abstract
ABSTRACT Thyroid function was studied before and after hypophysectomy in 30 patients (13 cases of metastatic mammary carcinoma, 12 cases of diabetes mellitus with retinopathy, and five cases of acromegaly). Attention was particularly focused on the relation of the changes produced in the basal metabolic rate (BMR) to the development of thyroid insufficiency. After hypophysectomy, hypothyroidism developed in all but six patients as judged from the postoperative levels of serum protein-bound iodine. However, a decrease in the BMR was observed postoperatively in all subjects. The effect of thyroid administration on the BMR was studied in 14 of the hypophysectomized patients. Thyroid therapy increased the BMR only moderately in most cases while restoration of the values to the preoperative level only occurred in one patient. It thus appears that the decreased BMR after hypophysectomy is not only dependent on thyroid insufficiency. The clinical manifestations of post-hypophysectomy hypothyroidism, were on the whole only slight and comprised mainly intolerance to cold and dryness of the skin. Myxoedema did not develop during an observation period up to 47 months after operation.
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