Iodine and Magnesium Levels in Maternal and Umbilical Cord Blood of Preeclamptic and Normal Pregnant Women

Abstract

The objective of this study was to investigate the relationship between preeclampsia and iodine levels and magnesium concentration in the blood of subjects in the northeast Anatolia region where iodine deficiency is common. Blood specimens were obtained from 24 preeclamptic and 16 healthy pregnant women. Iodine levels in blood were determined by the Foss method based on the Sandell-Kolthoff reaction. Serum protein-bound iodine (PBI) levels and magnesium concentration in maternal blood were lower in patients with severe preeclampsia compared to normal pregnant women (8.46 +/- 1.22 vs. 11.46 +/- 1.71 microg/dL, p < 0.001, 1.63 +/- 0.05 vs. 1.86 +/- 0.05 mg/dL, p < 0.001, respectively). Serum PBI levels and magnesium concentration in umbilical cord blood were higher in patients with severe preeclampsia than in normal pregnant women (8.84 +/- 1.9 vs. 7.33 +/- 1.07 microg/dL, p < 0.05, 2.48 +/- 0.03 vs. 2.02 +/- 0.01 mg/dL, p < 0.001, respectively). There was a positive correlation between the serum PBI levels in maternal blood and magnesium concentration in maternal blood in patients with severe preeclampsia (r = 0.41, p < 0.05). Thus, iodine may be one factor contributing to the pathophysiology of preeclampsia. Iodine supplementation may be effective therapy in preeclamptic in pregnant women.