Abstract
Background: Chronic Kidney Disease (CKD) is a public health problem that tends to take dimensions of epidemic and has serious impact on quality of patients life. Thyroid function disorders are common in patients with chronic kidney disease. Aim: The aim of the present study was to explore the conditions of Thyroid Disorders and Biological parameters in chronic kidney disease patients having psychiatric morbidity undergoing haemodialysis. Materials and Methods: Prospective study included 130 participants undergoing haemodialysis with Psychiatric morbidity. Exclusion criteria were: previous thyroid disorders, systemic illnesses, critically ill patients. Blood samples were taken for standard laboratory analysis, total and free thyroid hormone levels. Results: On comparing patients with and without psychiatric illness and their potassium values, there was a significant association (p< 0.05) between abnormal potassium values and psychiatric illness. There was a significant association (p< 0.05) between psychiatric illness and total bilirubin values. The thyroid profile, there was a significant association (p< 0.05) between abnormal FT3, FT4 values and psychiatric illness. Conclusions: Our study showed that functional thyroid gland disorders are more common among patients having psychiatric morbidity undergoing haemodialysis compared with healthy subjects and reveal their link with time on dialysis.
Highlights
Chronic kidney disease (CKD) influence hypothalamo- pituitary-thyroid axis
Chronic Kidney Disease (CKD) affects the thyroid function by lowering levels of circulating the thyroid hormones and interfering with hormones it will bind to the protein carriers, disrupting metabolism and elimination of thyroid hormones[3] and affect the storage of iodine in thyroid gland[4]
Total and free T4 can be increased in haemodialysed patients due to lipolitic effects of heparin used in anticoagulant therapy during haemodialysis 8
Summary
Chronic kidney disease (CKD) influence hypothalamo- pituitary-thyroid axis. Thyroid stimulating hormone (TSH) is disturbed in uraemia and the TSH response to the hypothalamic thyrotrophic releasing hormone (TRH) is reduced[1,2]. Chronic Hemodialysis (HD) is associated with abnormal concentrations of circulating thyroid hormones; mainly the reduction of total and free serum thyrotrophin (T3). The aim of this study was to compare thyroid function among patients on chronic haemodialysis and healthy participants and to assess if there is an association between the dialysis duration and thyroid disorders. Thyroid function disorders are common in patients with chronic kidney disease. Aim: The aim of the present study was to explore the conditions of Thyroid Disorders and Biological parameters in chronic kidney disease patients having psychiatric morbidity undergoing haemodialysis. Conclusions: Our study showed that functional thyroid gland disorders are more common among patients having psychiatric morbidity undergoing haemodialysis compared with healthy subjects and reveal their link with time on dialysis.
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