Abstract
BackgroundThe liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body. Long-term, high-dose dexamethasone administration can cause severe alterations in liver function. Therefore, Thymus vulgaris leave extract possess a modulatory role on dexamethasone-induced hepatotoxicity by attenuating antioxidant defense system.By subcutaneous route, animals will receive three doses per week for 8 weeks of dexamethasone (0.1 mg/kg. b. wt.) concomitant with oral administration of thyme aqueous extract (500 mg/kg b.wt.).ResultsDXM treatment led to a marked increase in the liver function enzyme activities that are successfully ameliorated by thyme aqueous extract. Thyme natural antioxidants augmented the antioxidant defense system that overcomes oxidative stress caused by dexamethasone. Conversely, although dexamethasone-treated animals rose lipid peroxidation, thyme extract pretreatment did the reverse.ConclusionHepatotoxicity and oxidative stress caused by dexamethasone might improve by thyme natural antioxidants.
Highlights
The liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body
Serum levels of cholesterol, bilirubin, transaminases, triglycerides, and alkaline phosphatase are raised in hepatic disease [4, 42]
Animals treated with thyme caused a great elevation of the liver glutathione level that was markedly increased; the proportion was 89.02% as competed with DXM-treated animals (− 44.76), which revealed important reduction in reduced glutathione level paralleled to non-treated animals
Summary
The liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body. Long-term, high-dose dexamethasone administration can cause severe alterations in liver function. The liver is the main site for powerful metabolism and elimination of chemicals, foreign substances, drugs, and toxic mixtures. Damage in the hepatic tissue accompanied by elevated tissue malonaldialdehyde, cellular necrosis, and reduced glutathione levels was diminished. Serum levels of cholesterol, bilirubin, transaminases, triglycerides, and alkaline phosphatase are raised in hepatic disease [4, 42]. The ingestion of dexamethasone overdose wastes its effect as a longacting anti-inflammatory synthetic steroid [29]. Synthetic and natural glucocorticoids are considered as a leader of the anti-inflammatory and immunosuppressive treatments
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