Abstract
We report here a case of thymoma simultaneously associated with undifferentiated pleomorphic sarcoma. A 45-year-old male presented with axillary lump. Radiographic studies showed a mediastinal mass. On fine needle aspiration cytology and histopathological examination, a diagnosis of thymoma with coexisting undifferentiated pleomorphic sarcoma was made. Although thymomas are associated with many extrathymic malignancies, it's association with undifferentiated pleomorphic sarcoma is rare. This case is being reported on to reinforce that clinicians should bear in mind the possibility of extrathymic malignancies in patients with thymomas.
Highlights
Thymoma is a tumor of anterior mediastinum, thymomas may develop at various other sites like neck, trachea, thyroid, lung, and heart [1]
Thymoma is an uncommon neoplasm which arises from thymic epithelium
We report here a case of mediastinal thymoma with coexisting axillary pleomorphic sarcoma
Summary
Thymoma is a tumor of anterior mediastinum, thymomas may develop at various other sites like neck, trachea, thyroid, lung, and heart [1]. It is the most common neoplasm of thymus, more common in men and in eighth decade of life [2]. Thymomas are associated with paraneoplastic syndromes such as myasthenia gravis, hypogammaglobulinemia [3], pure red cell aplasia [4], and many kinds of immune mediated systemic disorders; few cases of extrathymic malignancies have been reported. Reported incidence of extrathymic malignancies is 2.6%–27% [5,6,7,8]. We report here a case of mediastinal thymoma with coexisting axillary pleomorphic sarcoma
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