Abstract
Two new thymol derivatives (compounds 1–2) were isolated from the roots of Eupatorium chinense. Their structures were elucidated by analysis of MS data and extensive 1D and 2D NMR spectroscopy (1H-1H COSY, HMBC, HSQC and NOESY). The absolute configuration of compound 1 was assigned based on a comparison of calculated and experimental ECD. Compounds 1–2 were tested in vitro for their cytotoxic activities against three cancer cell lines CNE 2, Caski and HGC-27. Among them, compound 1 showed notable cytotoxic activities against the three cancer cell lines with IC50 values ranging from 4.2 to 11.9 μM.
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