THU0017 Deferoxamine Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Articular Cartilage via A Process Involving Downregulation of Protease Activity, Proinflammatory Cytokines and Type X Collagen Expression and Upregulation of AMPK and Citric Acid Cycle Genes

Abstract

BackgroundOsteoarthritis (OA) involves degenerative changes in articular cartilage, remodelling of subchondral bone and limited synovial inflammation. Osteoarthritic changes in articular cartilage are associated with progressive proteolytic degradation of the extracellular...