Thrombolytic Therapy for Stroke

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Part I. Background and Basic Investigations. Mechanisms of Thrombolysis, Gregory J. del Zoppo and Naohisa Hosomi. Pathogenesis of Cervico-cranial Artery Occlusion, Louis R. Caplan. The Ischemic Penumbra and Neuronal Salvage, Patrick D. Lyden. Part II. Scientific Rationale and Clinical Trials. Pre-Clinical Testing of Thrombolytic Therapy for Stroke, Anne M. Guyot and Steven R. Levine. Combination of Thrombolytic Therapy with Neuroprotectants, James C. Grotta. Early Studies of Thrombolytic Therapy for Stroke, Anne M. Guyot, Luchi Quinones, and Steven R. Levine. Phase 2 Experience with Intravenous Thrombolytic Therapy for Acute Ischemic Stroke, E. Clarke Haley, Jr. Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large, Randomized Clinical Trials, Rashmi U. Kothari and Joseph P. Broderick. Further Analysis of NINDS Study: Long-Term Outcome, Subgroups, and Cost Effectiveness, Susan C. Fagan, Thomas Kwiatkowski, and Patrick D. Lyden. Intra-Arterial Thrombolysis in Acute Ischemic Stroke, Anthony J. Furlan, Randall Higashida, Irene Katzan, and Alex Abou-Chebl. Combinations of Intravenous and Intra-Arterial Thrombolysis, Joseph P. Broderick and Rashmi Kothari. Part III. Using Thrombolysis for Acute Stroke. The Case for Thrombolytic Therapy in Stroke Patients, Patrick D. Lyden. The Case Against the Present Guidelines for Stroke Thrombolysis: The Present Recommendations for Clinical Use Should Be Modified, Louis R. Caplan. How to Run a Code Stroke, Christopher Lewandowski. Interpretation of CT Scans for Acute Stroke, Rudiger von Kummer. Identifying and Overcoming Obstacles to Acute Stroke Treatment with rt-PA: Establishing Hospital and EMS Protocols, Karen S. Rapp and Patti Bratina. The NINDS t-PA for Acute Stroke Protocol, John R. Marler and Patrick D. Lyden. Research Directions and the Future of Stroke Therapy, Patrick D. Lyden. Part IV. Illustrative Cases. Illustrative Cases. Index.