Abstract
of initial NlHSSS >10 in the NINDS study (42%). PROACf II ended patient accrual August 24, 1998, and results may be available by this meeting. In the future, LIF reports must include documentation of the initial neurologic deficit, as measured by the NIHSSS, and outcomes as measured by the Barthel Index and Rankin Score, so relative comparison to NlNDS and ECASS data can be derived. Stratification for treatment based on initial NIHSSS or early imaging to document the area of infarction and potential major vessel occlu. sion is a concept that is being pursued. Documentation that LIF is superior to IV therapy in clinical benefit, with acceptable safety, awaits a comparison study of IV-tPA versus IA LIF or some other therapy that allows direct clot removal, with or without additional combination therapy.
Published Version
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