THREE-DIMENSIONAL GAIT ANALYSIS AS A POTENTIAL AND QUANTIFIABLE MEASUREMENT IN THE CLINICAL EVALUATION OF ANKYLOSING SPONDYLITIS

Abstract

The present study aimed to investigate the potential clinical value of three-dimensional gait analysis (3D-GA) system in evaluating ankylosing spondylitis (AS). Thirty-one patients with AS from September 2010 to August 2011, with 32 involved and 30 uninvolved lower limbs, were enrolled. Data of spatio-temporal parameters (step and stride length, velocity and cadence), time parameters (stance, single stance, double stance and swing phases) and kinematics parameters associated with spinal mobility (spinal lateral bending, spinal forward bending and spinal rotation) were analyzed by 3D-GA system, as well as curative effects of biologic therapy. Compared with normal values, AS patients showed decreased step and stride length ([Formula: see text]), increased cadence, longer swing and single stance phases ([Formula: see text]) and shorter stance and double stance phases ([Formula: see text]) in uninvolved lower limbs. In AS patients, reduced step length, stride length, velocity and cadence, shorter swing and single stance phases, longer stance and double stance phases ([Formula: see text]), increased lateral bending angle and decreased spinal rotation ([Formula: see text]) were detected by 3D-GA in involved lower limbs compared with uninvolved ones. In the 16 patients with decreased levels of ESR and CRP and improved ASAS scores after biology therapy, increased step length, stride length, velocity and cadence of the involved lower limbs were detected by 3D-GA ([Formula: see text]), as well as improved spinal mobility ([Formula: see text]). Hence, we concluded that 3D-GA has great potential value of clinical application for assessing and monitoring AS.