Three-dimensional atlas framework for mapping of projections from the entorhinal cortex to the hippocampal formation in rat

Abstract

Event Abstract Back to Event Three-dimensional atlas framework for mapping of projections from the entorhinal cortex to the hippocampal formation in rat Lisa J Kjønigsen1*, Trygve B Leergaard1, Menno P Witter2 and Jan G Bjaalie1 1 University of Oslo, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, Norway 2 VU University Medial Centre, Deptartment of Anatomy & Neuroscience, Netherlands Precise maps of the complex neural networks connecting different parts of the hippocampal formation and parahippocampus are needed to advance our understanding of mechanisms underlying memory and learning processes. The entorhinal cortex provides an interface between the hippocampal formation and the neocortex, and is considered to have a pivotal role in memory formation by gating signals to the hippocampus. Numerous investigations of the axonal connections between the entorhinal cortex and the hippocampal formation have provided an overwhelming amount of data describing laminar and topological patterns of organization. It is, however, challenging to appreciate both the subtle details as well as the overall organizational principles of these complex networks. To this end we have established a three-dimensional (3-D) atlas of the entorhinal projections to the hippocampal formation in rat. The atlas contains data from five experiments, in which an anterograde axonal tracer was injected at different locations in the entorhinal cortex. Images of histological sections showing the detailed trajectory of labelled axons are organized in a 3-D spatial framework, and image analysis tools are used to derive simplified representations of labelled axonal terminals. We demonstrate and compare regional and subregional topographical organization in the hippocampal formation. We conclude that this neuroinformatics based approach provides a powerful framework for gaining an overview of hippocampal neural networks, while simultaneously maintaining access to morphological details present in the original histological data. Keywords: digital atlasing Conference: 4th INCF Congress of Neuroinformatics, Boston, United States, 4 Sep - 6 Sep, 2011. Presentation Type: Poster Presentation Topic: Digital atlasing Citation: Kjønigsen L, Leergaard T, Witter M and Bjaalie J (2011). Three-dimensional atlas framework for mapping of projections from the entorhinal cortex to the hippocampal formation in rat. Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics. doi: 10.3389/conf.fninf.2011.08.00129 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Oct 2011; Published Online: 19 Oct 2011. * Correspondence: Dr. Lisa J Kjønigsen, University of Oslo, Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, Oslo, Norway, l.j.kjonigsen@medisin.uio.no Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lisa J Kjønigsen Trygve B Leergaard Menno P Witter Jan G Bjaalie Google Lisa J Kjønigsen Trygve B Leergaard Menno P Witter Jan G Bjaalie Google Scholar Lisa J Kjønigsen Trygve B Leergaard Menno P Witter Jan G Bjaalie PubMed Lisa J Kjønigsen Trygve B Leergaard Menno P Witter Jan G Bjaalie Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.