Abstract

The three-component domino reaction involving 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes, and cyclic NH-acids is a new method for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines containing in position 3, cyclic nitrogen-containing fragments. The transformation is performed under microwave irradiation in dry acetonitrile at 130 °C.

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