Abstract
Background/aim Application fields of bone tissue engineering studies continue to expand. New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Our objective in this study is to combine polylactic acid which is a polymer with hydroxyapatite in the repairment of bone defects considering the increased need by medical application fields. Materials and methods After 750 g of PLA with a diameter of 2.85 mm was granulated into minimum particles, these particles were homogenously mixed with hydroxyapatite prepared in laboratory environment. Using this mixture, HA-PLA filament with a diameter of 2.85 mm was prepared in the extrusion device in Kütahya Medical Sciences University Innovative Technology Laboratory. The temperature was 250 °C and the gearmotor speed was 9 rpm during extrusion. X-ray diffraction (XRD) analysis was made for crystal phase analyses of the produced hydroxyapatite powder, to determine the produced main phase and examine whether a minor phase occurred. Vickers microhardness test was applied on both samples to measure the endurance levels of the samples prepared with HA-PLA filament. A loading force of 10 kg was applied on the samples for 10 s.Results Hydroxyapatite peaks in XRD spectrum of the sample presented in figures are concordant with Joint Committee on Powder Diffraction Standards, JCPDS - File Card No. 01-075-9526 and no significant minor phase was observed. For both samples, hardness value was observed to increase between 3 and 5 mm.Conclusion Surfacing hydroxyapatite on metallic materials is possible. By similar logic, to increase durability with low cost, characteristics of biomaterials can be improved with combinations such as hydroxyapatite PLA. Thus, we found that while these materials have usage limitations due to present disadvantages when used alone, it is possible to increase their efficiency and availability through different combinations.
Highlights
Application fields of bone tissue engineering studies continue to enlarge
Hydroxyapatite peaks in X-ray diffraction (XRD) spectrum of the sample presented in figures are concordant with Joint Committee on Powder Diffraction Standards, JCPDS - File Card No 01-075-9526 and no significant minor phase was observed
To increase durability with low cost, characteristics of biomaterials can be improved with combinations such as hydroxyapatite polylactic acid (PLA)
Summary
New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Hydroxyapatite, collagen, hyaluronic acid, poly fumarates, poly caprolactone, polylactic acid (PLA), polyglycolic acid (PGA), and PLA and PGA copolymers are some of the biomaterials used in medical field. Characteristics of these materials such as durability and compatibility were increased by combinations. KAYA et al / Turk J Med Sci to implant applications, biomaterials are used for bone tissue regeneration. Repair work of biomaterials on hard tissues such as bone began with ‘bone bonding’ defined by Williams et al in 1992 and has advanced quickly since [2]
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