Threat Conditioning and Trait-Based Vulnerability to Personality Disorder.

Abstract

Some personality disorders (PDs) are accompanied by heightened threat sensitivity to benign events, whereas others are associated with minimal reactivity to danger or punishment. Such aberrant patterns of defensive responding may be due to abnormal threat learning processes, analogous to those observed in other fear- and fearlessness-based disorders. We investigated threat learning deficits with a Pavlovian differential conditioning procedure in an undergraduate sample (n = 117) overselected for negative affectivity. Contrary to predictions, maladaptive personality traits, as assessed via the Personality Inventory for DSM-5, were largely unrelated to defensive responding (i.e., subjective and electrodermal reactions to danger and safety cues) during threat conditioning. We discuss the possible boundary conditions of threat learning abnormalities in PD and suggest research designs that could more effectively reveal such deficits, if they exist.