Abstract
The designing of chemosensors is a fascinating and growing research field among the scientific community. This article emphasizes the synthesis of thiosemicarbazone-triazole bearing siloxy framework (5a-5c)by utilizing an effective and biocompatible Cu(I) catalyzed “Click Silylation” approach. All the newly synthesized compounds (4a-4cand5a-5c)have been well-characterized by various spectroscopy techniques like Infrared, Nuclear Magnetic Rasonance (1H NMR and 13C NMR), mass spectrometry and Thermogravimetric Analysis. The photophysical properties of5aand its precursor alkyne4awere investigated by employing UV-vis spectroscopy, which showed the selective and sensitive recognition of Hg2+ and Cu2+ ions with negligible interference from different metal ions. All types of the binding interaction between chemosensors (4a/5a)and Hg2+/Cu2+ ions got reversed upon addition of salt of ethylene diamminetetraacetic acid. The association constant and limit of detection values were also determined by plotting BH-plot and linear calibration curve respectively. Furthermore, the cytotoxic activity results indicate that the siloxy compounds were found to be excellent postulants compared to ascorbic acid and hence can be applied for biological purposes.
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