Abstract
Thioredoxin(TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and has excellent anti-inflammatory effect in treating animal models of various inflammatory diseases. We have previously demonstrated that the irritant dermatitis to croton oil was attenuated in human TRX-overexpressing mice, but it remains unclear whether administration of recombinant human TRX protein has therapeutic effects on the irritant dermatitis. Here we showed that swelling and the infiltration of neutrophils were strongly inhibited by application of rhTRX in irritant dermatitis to croton oil.
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