Abstract
HSP60: a double edge sword in autoimmunity.
Highlights
HSP60 is a highly conserved protein, which was initially characterized as a mitochondrial chaperone
HSP60 is overexpressed in inflamed lesions of atopic dermatitis where it is co-localized with CD3 positive cells [4]
Several supporting evidence for the pathogenicity of HSP60 have been reported in experimental animal models of inflammatory diseases
Summary
HSP60 is a highly conserved protein, which was initially characterized as a mitochondrial chaperone. HSP60 induces IFNγ secretion from atopic dermatitis patients’ PBMCs [4] and PBMCs of patients with BD, stimulated with various epitopes of HSP60, resulted in excess amounts of Th1 cytokine production [2]. Several supporting evidence for the pathogenicity of HSP60 have been reported in experimental animal models of inflammatory diseases.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
