Abstract
Introduction: Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters. Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods. Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion: The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.
Highlights
Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders
Our aim of study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1, arylesterase, ischemiamodified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters
The deterioration resulting from oxidation in nativetotal thiol balance may be a laboratory indicator for pediatric specific learning disorders patients
Summary
The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters. Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. They refer to problems that continue in one of three areas: reading, writing and mathematics, and they form the basis of one’s learning ability. Our aim of study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1, arylesterase, ischemiamodified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters
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