Abstract
Objective: Peripheral artery disease (PAD) is the name given to blocked blood flow in major arteries other than cerebral and coronary circulation. The diagnosis and treatment of PAD is very important because of the high frequency of PAD. In this study, it was aimed to investigate the possible change in next generation oxidative stress-antioxidant status indicators as a biochemical parameter that may be useful in the diagnosis and follow-up of PAD. Method: Forty healthy controls and 40 male and female patients with peripheral artery disease who applied to the Alanya Alaaddin Keykubat University Research and Training Hospital were enrolled in the study on a voluntary basis. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia modified albumin (IMA) and Thiol balance were studied with the colorimetric method. Results: The TOS (p <0.001), OSI (p <0.001), IMA (p = 0.027), total thiol (0.004) levels were higher in the peripheral artery patients compared to the control group, while the TAS (p <0.001) and native thiol / total thiol ratio (index 3) (p = 0.018) values were significantly lower. Conclusion: The increase in TOS and IMA levels may be used as an indicator of peripheral artery disease. There is an increase in inflammation in the ischemia and atherosclerosis processes. An ischemia-specific protein called ischemia-modified albumin may be used as a rapid and practical laboratory marker in common peripheral artery disease.
Highlights
Peripheral artery disease (PAD) is the name given to the blocking of blood flow in major arteries other than cerebral and coronary circulation
There is an increase in inflammation in the ischemia and atherosclerosis processes
The present study aimed to investigate the possible change in generation oxidative stressantioxidant status indicators as a biochemical parameter that could be useful in the diagnosis and follow-up of PAD
Summary
Peripheral artery disease (PAD) is the name given to the blocking of blood flow in major arteries other than cerebral and coronary circulation. The most common condition that causes PAD is atherosclerosis. PAD usually occurs in the lower extremities and leads to increased mortality. PAD often exhibits silent picture in its clinical course. Since PAD has silent clinical course, possible laboratory parameters that can provide early diagnosis of the disease are very valuable. PAD follows a clinical course ranging from a simple leg pain to limb loss. Over the age of 80, the frequency of PAD exceeds 40%. The diagnosis and treatment of PAD are very important due to the high frequency of PAD, leading to increased morbidity and mortality [1,2,3]. Oxidative stress and antioxidant status are in equilibrium in organisms. Increased oxidative stress is likely to cause an increase in the frequency of PAD.
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