Abstract
Established changes in expression levels and relationships between the levels of the Nos2 and Mmp-9 genes under physiological conditions and at all stages of the experiment (p<0.05), as well as between the levels of the Yap1 and Tweak genes at all stages of fibrosis (p<0.05) with the exception of the stage of complete cirrhosis, with a high degree of probability indicate the participation of these genes in the development of toxic fibrosis and cirrhosis of the liver. MicroRNA-19a-3p, microRNA-29b-3p, microRNA-195-5p, microRNA-466d, microRNA-489-3p, microRNA-495, microRNA-664-3p, microRNA-3558-3p are associated with Mmp-9 mRNA levels, Nos2, Yap1 at different stages of liver fibrosis and cirrhosis (p<0.05) and, probably, these microRNAs are involved in these pathological processes in one way or another.
Published Version
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