Abstract
The past five decades of molecular genetics have produced many discoveries about genome structure and function that can only be understood from an informatic perspective: --- distinct sequence codes to mark the individual steps in packaging, expression, replication, transmission, repair and restructuring of DNA molecules; --- modularity of data files for RNA and protein products; --- combinatoric organization of signals to format the genome for differential functioning during cellular and organismal cycles; --- direct participation of DNA in the execution of biological algorithms (formation of highly structured nucleoprotein complexes); --- hierarchical organization of genomic subsystems to form higher level system architectures. This review will discuss aspects of genome organization and genome change that require a more formal computational analysis. We will see how modern results indicate that genome evolution has many similarities to computer system engineering. The ability of cells to control the function of natural genetic engineering systems is central to the genome's potential as a Read---Write information storage system.
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