Abstract

VEXAS syndrome is a rare auto-inflammatory disorder characterized by heterogeneous inflammatory and hematologic features. First identified in 2020, it predominantly affects men over the age of 50. Clinical manifestations commonly include recurrent fever, weight loss, skin lesions, and diverse inflammatory presentations across multiple organ systems. Diagnosing VEXAS syndrome can be challenging due to the overlap of symptoms with other autoimmune and inflammatory conditions, often requiring extensive medical evaluation before a definitive diagnosis is made. This case report highlights these diagnostic challenges and underscores the importance of early recognition to improve clinical management and outcomes.

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