Abstract
With the increase of the 3-substituted ether side-chain, the polarity of the molecules decreases. However, this decrease is not accompained by a great variation in the TLC properties, and so derivatives the molecular weights of which are not very different are difficult to separate. On the other hand, ethers containing an iso, unsaturated, cycloalkyl or aromatic side-chain can readily be separated. The separation of the esters similarly causes no problems. For the ketones the linear polarity-decrease as a function of the molecular weight is the most pronounced for the oximes, but it also appears for the lactams in certain systems. For the d-homo-lactams, which have the same molecular weights as the oximes, the separation can be solved only in those systems where the nonpolar component is in great excess over the polar one.
Published Version
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