Abstract
A thin-layer chromatographic method is described for polyhedric diterpene acetates derived from irritant and co-carcinogenic principles from the Croton and Euphorbia genera of the family Euphorbiaceae. The method consists of an acetylation procedure for the free alcohols followed by thin-layer chromatographic separation and colour reactions on silica gel and alumina with several different solvent mixtures and sprays. Migration is governed by the number and stereochemical configuration of the free hydroxyl groups in rings A and B of the tetracyclic structure and to a lesser degree by the number and configuration of acetate moieties. This provides a rapid micro-screening procedure for these diterpenes, which is readily supported by mass spectra of small quantities recovered from thin-layer plates.
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