Abstract
The colonization of biomaterials with bacteria represents the main cause of implant-associated infections. Both an antibiotic prophylaxis and a faster osteointegration can be obtained by incorporation of bactericidal active metals in degradable CaP coatings. At present there is no reliable method on the basis of thermal spraying to get thin homogeneous layers containing silver, copper and bismuth in bacteriostatic / bactericidal concentrations. The aim of the study was the development and optimization of high-velocity suspension flame spraying (HVSFS) process for producing thin resorbable bioactive ceramics coatings on the basis of degradable calcium phosphates. In these layers the bacteriostatic / bactericidal effective metal copper should be integrated. Cells were grown on the materials for 3, 7, 14, and 21 days. Live/dead assay was used to measure cell viability. The in vitro cytotoxicity was determined by the microculture tetrazolium (WST) assay. Cell morphology, cell attachment, and cell spreading were investigated using laser scanning microscopy and raster scanning electron microscopy. All substrates supported sufficient cellular growth for 21 days and showed no cytotoxicity. On each material an identical cell colonisation of well communicating, polygonal, vital cells was verified
Highlights
Arthroplasty is an effective treatment for severe trauma and arthritic joint diseases.Aseptic loosening has been acknowledged as one of the leading causes of revisions procedures in patients with previous joint arthroplasty [1]
Each coating consists of a resorbable osteoconductive ceramic component, and an antimicrobial-active metal component
The surface roughness values were found to be in a range from 7.25 μm (GB14 + Ag) to 15.50
Summary
Aseptic loosening has been acknowledged as one of the leading causes of revisions procedures in patients with previous joint arthroplasty [1]. This phenomenon is attributable to the missing induction of secondary stability; meaning that the firm anchorage needed between the prosthesis and the surrounding bone on a long term is missing [2,3]. Another common complication after implantation is microbial colonization on the prosthesis surface [4]. Each coating consists of a resorbable osteoconductive ceramic component, and an antimicrobial-active metal component
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