Thiazolidines to lock cis Xaa-Pro amide bond: new synthetic approach

Abstract

Abstract Thiazolidines, especially the 2,2-dimethylated residue Cys(Ψ Me,Me pro), are efficient tools to lock Xaa-Pro amide bond to the cis conformation. We investigated herein a new synthetic approach to incorporate these proline mimics instead of the proline into a peptide sequence using N α-protected derivatives by a fluorenylmethyl or an allyl carbamate. To cite this article: S. Chierici et al., C. R. Chimie 8 (2005) .