Abstract
Isolation and Characterization of a Novel ConusPeptide with Apparent Antinociceptive Activity
Highlights
Conus is a genus of predatory marine gastropods that envenomate their prey
Prey capture is accomplished through a sophisticated arsenal of peptides that target specific ion channel and receptor subtypes
Conus peptides that target voltage-gated ion channels include those that delay the inactivation of sodium channels as well as blockers specific for sodium channels, calcium channels, and potassium channels
Summary
Electrospray ionization mass spectra were measured using a Micromass Quattro II Triple Quadrupole Mass Spectrometer with Micromass MassLynx operating system. The samples (ϳ100 pmol) were resuspended in 0.1 ml of 50% acetonitrile with 0.05% trifluoroacetic acid and automatically infused with a flow rate of 0.05 ml/min in the same solvent system. The instrument was scanned over the m/z range 50 – 2,000 with a capillary voltage of 2.95 kV and a cone voltage of 64 V. The resulting data were analyzed using MassLynx software
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