Thiamine hydrochloride (vitamin B1) catalyzed greener synthesis of thiazolidin-4-one derivatives

Abstract

Eco-friendly synthesis of thiazolidin-4-one scaffolds has been accomplished by the one-pot protocol. Thiazolidin-4-one scaffolds were obtained by multicomponent cyclo condensation of aromatic amine, a carbonyl compound, and a thioglycolic acid in thiamine hydrochloride (vitamin B1) as a biodegradable catalyst in acetonitrile solvent. The structure of the synthesized thiazolidin-4-one was elucidated by FT-IR, Proton nuclear magnetic resonance, and HR-MS spectral techniques. The reported route possesses outstanding features includes; efficient, cost-effective, easy work-up procedure, high yield, and biodegradable catalyst.