Abstract
Thiamethoxam is one of the second-generation neonicotinoids, a new class of insecticides. The study was designed to investigate the effect of thiamethoxam on fertility in bucks. For this purpose, sixteen male adult male chinchilla rabbits were divided in two groups. Thiamethoxam intoxicated group was treated with thiamethoxam at dose of 250 mg/Kg body weight for 3 months. Semen analysis revealed distinct changes in sperm characteristics including significant decrease in sperm motility (both mass and individual) and sperm count. In addition, significant increase in dead spermatozoa and sperm deformities. Moreover, elevation in testicular concentration of MDA and GST was significant. GSH was significantly decreased. Degeneration and necrosis of spermatogenic cells with intertubular edema and vacuolations in seminiferous tubules were the major observed histopathological changes in the testis of intoxicated animals. In conclusion, thiamethoxam administration for 3 months induced significant decrease in fertility and oxidative stress in the reproductive system of adult male.
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