Abstract
Objective: The present study was planned to develop thermo-reversible in-situ gel for the treatment of allergic rhinitis (AR). The objective of the present investigation was to develop a mucoadhesive in-situ gel with reduced nasal mucocilliary clearance to improve the local effect of the polyherbal extract in the treatment of allergic rhinitis (AR). The prolonged residence of drug formulation in the nasal cavity is one of utmost importance for intranasal drug delivery. The prepared formulations were subjected for gelling temperature, gelling time, viscosity, gel strength, pH, drug content, mucoadhesive strength, spread ability and irritancy studies.Methods: In the study the pluronic F127 (PF127) based mucoadhesive in-situ nasal gels containing Moringa olifera (MO) and Embelia ribes (ER) extracts were used having antioxidant and anti-inflammatory effect. A polyherbal thermosensitive in-situ hydrogel was designed and evaluated by the mixing of pluronic F127, poly (ethylene glycol) (PEG400) and Xanthan gum with a small amount of (hydroxypropyl methylcellulose) HPMC K4M and Carbopol 934. Total 13 thermosensitive in-situ gels of extracts were prepared through combination of HPMC K4M or Carbopol or xanthan gum and PF127. All the preparations were investigated, and the selected method for gel formation underwent the thermal transition from sol to hydrogel.Results: The mucoadhesive gel after being administered into the nasal cavity, get transformed into the viscous hydrogel at body temperature, which diminished nasal mucociliary clearance and prolonged the duration of action. The in-situ nasal herbal gel prepared by combination of different concentration of to HPMC K4M or carbopol or xanthan gum with PF127 (10% w/v) produces the better and effective gel. The findings of evaluation parameter indicate that the in-situ gel prepared by combination with corbopol were better quality compared to HPMC K4M and xanthan gum.Conclusion: From these findings, it can be concluded that in-situ herbal nasal gels may be potential drug delivery systems for Moringa olifera and Embelia ribes extracts to overcome first-pass metabolism and thereby to improve the bioavailability. The mucoadhesive in-situ gel system is a promising approach for the intranasal delivery of polyherbal extracts for the therapeutic effects improvement of Allergic rhinitis.
Highlights
Allergic rhinitis (AR) is a heterogeneous disorder, which is often characterized by mucosal infiltration and actions of eosinophils, plasma cells, and mast cells
The in-situ nasal herbal gel prepared by combination of different concentration of to HPMC K4M or carbopol or xanthan gum with pluronic F127 (PF127) (10% w/v) produces the better and effective gel
The findings of evaluation parameter indicate that the in-situ gel prepared by combination with corbopol were better quality compared to HPMC K4M and xanthan gum
Summary
Allergic rhinitis (AR) is a heterogeneous disorder, which is often characterized by mucosal infiltration and actions of eosinophils, plasma cells, and mast cells. This disorder is extremely widespread but its diagnosis and prevention is very poor. The practices of nasal formulation are limited due to associate constraints with drug delivery systems poses a major drawback. Plant extracts are different in several respects from purified therapeutic agents. They are more dilute than the pure chemicals that are familiar to us; secondly herbs often contain additional active principles that may be closely related both chemically and therapeutically to the constituent primarily responsible for its effects. Phytotherapeutics need a scientific approach to deliver the components in a sustained manner to increase patient compliance and avoid repeated administration [7]
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