Abstract
The present study investigated the change in thermoregulatory responses following microinjection of 5-hydroxytryptamine (5-HT) into the lateral septum and the hippocampus of unanesthetized, unrestrained rats. Intraseptal injection of 5-HT (5 to 20 μg) caused a dose-related fall in core temperature (T b), which was associated with a decrease in heat production (HP). As the decrease in HP can not completely account for the magnitude of the decrease in T b, increase in heat loss may also be involved in the 5-HT-induced hypothermia. In contrast to observed changes following intraseptal injection, no significant change in either T b or HP was observed after microinjection of the same doses of 5-HT into the hippocampal areas, indicating that the hypothermic response to intraseptal injection of 5-HT is site specific. Further, the hypothermic response to intraseptal injection of 5-HT was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-HT receptor, but not by endogenous opioid and cholinergic systems.
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