Abstract
Brainstem mechanisms involved in the central control of thermogenesis in brown adipose tissue (BAT) were investigated, in urethane-anaesthetized rats, by observing changes i the temperature of intrescapular BAT following electrical stimulation of sites in the dorsal raphe nucleus (DRN). Large increases in temperature could be produced by single 30 s stimulation trains. The magnitude of the temperature increase grew as a function of both current and frequency. Non-linear temporal summation was observed when near-threshold trains were delivered in close succession. These results are consistent with the view that ascending projections from the DRN relay thermal information to the basal forebrain and hypothalamus.
Published Version
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