Thermodynamics of the dissociations of ortho-, meta-, and para-aminobenzene sulphonic, glutamic and sulphamic acids in formamide at different temperatures

Abstract

The thermodynamic dissociation constants of orthanilic, metanilic, sulphanilic, glutamic and sulphamic acids in formamide have been determined from 5 to 45°C at intervals of 5°C. Electromotive force measurements in cells without liquid junction (using quinhydrone and silver—silver chloride electrodes) were made. The thermodynamic quantities associated with the ionization of these amino acids have been calculated. These quantities are discussed in relation to the structure of the acid and the orientation of formamide molecules by the ions.