Abstract
Understanding of the cellular role of nucleic acid triple helices and utilization of triple helix forming oligonucleotides in biotechnology, diagnostics, and therapeutics depend on development of an understanding of triple helix formation as a function of the nucleic acid components and solution conditions. This article reviews developments in nucleic acid triple helix thermodynamics with emphasis on the thermal and thermodynamic stability and their dependence on solution conditions. Special emphasis is placed on the construction and interpretation of state diagrams as a means of characterizing the complex behavior of triple helix forming oligonucleotides. Recent developments, which strive to overcome some of the limitations imposed by the natural nucleotide bases and sugar-phosphate backbone, are reviewed from a thermodynamic perspective. © 1998 John Wiley & Sons, Inc. Biopoly 44: 241–256, 1997
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
